Our mission is to develop curative T cell immunotherapies for the treatment of solid tumors. A major barrier to successful T cell therapies for solid tumors is the so-called “T cell exhaustion”: during a protracted battle with tumor cells, T cells can become fatigued and are no longer able to function properly and to fight tumor cells efficiently. To overcome this challenge, our vision is to generate antitumor T cells refractory to terminal differentiation and dysfunction by developing microRNA-based synthetic circuits capable of rewiring the transcriptional programs driving T cell exhaustion.
VISION & MISSION
![vision_mission_figure_a](https://www.t-fitness-horizon.eu/wp-content/uploads/2022/11/vision_mission_figure_a.png)
![vision_mission_figure_b](https://www.t-fitness-horizon.eu/wp-content/uploads/2022/11/vision_mission_figure_b.png)
LEFT: An exhausted T cell (grey) failing to attack a cancer cell (yellow).
RIGHT: A reprogrammed T cell with T-FITNESS technology (blue) fighting a cancer cell (yellow).